Mitochondrial defense mechanisms against glycation stress and development of novel drugs

Living organisms, including humans, are composed of individual cells. Within these cells, numerous proteins regulate various biological phenomena. To elucidate some aspects of these complex biological phenomena, our laboratory is focusing on mitochondria, one of the cellular organelles, and conducting basic research to elucidate the cell death mechanisms and defense mechanisms against glycation stress. Furthermore, based on the knowledge obtained from these basic studies, we are developing drug discovery to develop candidate therapeutics for age-related degenerative diseases of the eye and brain.